An article in the New York Times (July 26, 2013) describes the $1.3 million Pagani Huayra, produced one at a time with an annual volume of 20 vehicles and a life time run of 125 cars. Each car’s engine is assembled by a team of workers working one at a time. The individual vehicles are tested and tracked with every component traceable to a specific employee. For repairs, vehicles are fixed by a repair person flown to the site of the owner or the car is flown back to the plant in Italy. Are there lessons from this manufacturing, a craft and science mix that is reputed to recreate the philosophy of Leonardo da Vinci, for other products ? Will Italian competitiveness in manufacturing require a move to such niche manufacturing, and, if so, will it survive the challenge of globalization ? More importantly, will growth worldwide create a large enough demand for niche goods for it to become economical to revert to one piece custom manufacturing ?